Published Research Supporting TrueOrganic Formulations

Complete Scientific Documentation for HERS, HIS & Youth Product Lines

Our Commitment to Evidence-Based Skincare

TrueOrganic formulates based on published clinical research—combining evidence-based concentrations with advanced delivery systems and synergistic ingredients for maximum efficacy. This document provides complete citations and findings for all scientific claims referenced throughout our website.

Every formulation decision we make is informed by peer-reviewed research published in scientific journals. When we say "over 1,000mg pharmaceutical-grade CBD per jar," we can cite the exact study proving concentration matters. When we formulate our Dual-Pathway CB2 Complex at 4.4% total (CBD 2.4% + Copaiba 1.1% + Frankincense 0.9%), we're applying clinical research showing that delivery systems and synergistic ingredients maximize efficacy.

This is what separates TrueOrganic from conventional brands making vague "clinical" claims without evidence.

TrueOrganic Product Line Philosophy

Our three flagship facial creams are precision-engineered for distinct skin types, hormonal profiles, and age-related concerns:

HERS Rejuvenating Facial Cream

Target Demographic: Women 35-65 with mature, hormonally-affected, or sensitive skin

Key Formulation Strategy: Maximum anti-inflammatory support through Dual-Pathway CB2 Complex (4.4% total), natural retinoid alternatives (rosehip seed oil), barrier repair (prickly pear seed oil with 150% more vitamin E than argan), and hormonal balance support through premium fatty acid profile.

Signature Actives: CBD 2.4% (1,053mg), Copaiba 1.1%, Frankincense 0.9%, Rosehip seed oil (natural retinoids), Prickly pear seed oil (exceptional vitamin E), Sea buckthorn oil (omega-7), Bakuchiol (retinol alternative)

Clinical Focus: Anti-inflammatory pathways (CB2 + 5-LOX), cellular renewal without irritation, barrier optimization, collagen support, hormonal skin balance

HIS Rejuvenating Facial Cream

Target Demographic: Men 30-60 with thicker, oilier, or environmentally-stressed skin

Key Formulation Strategy: Enhanced barrier protection for thicker male skin (65% more dermis), sebum regulation through omega-5 (pomegranate), environmental defense (coffee seed oil caffeine), and cellular energetics (Gotu Kola for collagen synthesis). Masculine sensory profile with grounding essential oils.

Signature Actives: CBD 2.4% (1,053mg), Pomegranate seed oil (omega-5 punicic acid), Coffee seed oil (caffeine firming), Pumpkin seed oil (zinc + vitamin E), Baobab oil (vitamins A, D, E, F), Gotu Kola Ayurveda oil (collagen synthesis)

Clinical Focus: Enhanced penetration for thicker skin, sebum balance, environmental protection, collagen stimulation, cellular metabolism support

Youth Rejuvenating Facial Cream

Target Demographic: Young adults 18-35 with combination, acne-prone, or early preventative needs

Key Formulation Strategy: Lightweight non-comedogenic delivery system, exceptional vitamin C from Kakadu plum (world's highest natural source), preventative antioxidant protection through green tea EGCG, omega balance through hemp seed oil, and moderate CBD concentration optimized for younger skin metabolism.

Signature Actives: CBD 1.6% (703mg), Kakadu plum oil (highest natural vitamin C), Watermelon seed oil (lightweight omega-6 + 9), Hemp seed oil (optimal 3:1 omega-3:6 ratio), Green tea extract (EGCG polyphenols), Bakuchiol (gentle retinol alternative)

Clinical Focus: Prevention over correction, antioxidant protection, lightweight hydration without clogging, brightening, early collagen support, inflammation prevention

PRIMARY STUDIES CITED

These foundational studies inform TrueOrganic's formulation philosophy across all three product lines and are referenced throughout our website (How It Started, TrueOrganic Difference, Product Pages).

STUDY 1: CBD CONCENTRATION & SKIN DELIVERY

Full Citation: Paudel KS, Hammell DC, Agu RU, Valiveti S, Stinchcomb AL. "In vitro percutaneous absorption studies of cannabidiol using human skin: Exploring the effect of drug concentration, chemical enhancers, and essential oils." International Journal of Pharmaceutics. 2022 Mar 25;616:121540. doi: 10.1016/j.ijpharm.2022.121540. PMID: 35124116.

Study Type: In vitro percutaneous absorption study using human skin

Objective: To investigate the effect of CBD concentration on skin delivery and identify optimal therapeutic concentrations for topical application.

Methodology:

•       Franz diffusion cell method using human skin samples

•       Three concentrations tested: 1%, 5%, and 10% CBD

•       24-hour absorption study

•       Measurement of CBD penetration into skin tissue

Key Findings:

Concentration-Dependent Delivery:

•       1% CBD delivered: 23.02 ± 4.74 µg/cm² into skin tissue

•       5% CBD delivered: 242.41 ± 12.17 µg/cm² into skin tissue

•       10% CBD delivered: 232.79 ± 20.82 µg/cm² into skin tissue

Critical Conclusion: "1% delivered significantly lower amount of drug into skin than 5% and 10%"

Statistical Significance: The difference between 1% and 5-10% concentrations was statistically significant, demonstrating that concentrations below 5% deliver approximately 10 times less active ingredient into skin tissue.

Additional Finding: No significant difference between 5% and 10%, suggesting 5-10% is the optimal therapeutic range for topical CBD delivery in standard formulations.

How TrueOrganic Applies This Research Across Product Lines

Study Shows: 5-10% CBD delivers optimal skin penetration (10x more than 1%)

TrueOrganic Formulations:

•       HERS & HIS: 2.4% CBD (1,053mg per 44ml jar)

•       Youth: 1.6% CBD (703mg per 44ml jar) – optimized for younger skin metabolism and lower inflammatory baseline

While our concentrations are below the study's identified optimal range for standard formulations, we've engineered our formulations to maximize the efficacy of our CBD through multiple enhancement strategies:

1. 100% Anhydrous Delivery System

•       Oil-based formulations enhance lipophilic active penetration

•       No water = no emulsifiers blocking absorption

•       No synthetic penetration enhancers needed

•       Superior stability (no CBD degradation from water exposure)

2. Dual-Source CBD for Synergistic Benefits

•       Pharmaceutical-Grade CBD Isolate: 10g per batch (HERS/HIS), 7g per batch (Youth) – 99%+ purity

•       Full-Spectrum CBD Blend: 533mg per batch (entourage effect)

•       Two forms = broader cannabinoid profile

•       Enhanced through hemp/grapeseed carrier oils (50/50 blend at 1000mg/ml)

3. CB2 Receptor Amplification (HERS & HIS)

•       Copaiba Essential Oil (1.1%) - Beta-caryophyllene acts as CB2 agonist

•       Research shows beta-caryophyllene enhances cannabinoid receptor activation

•       Synergistic effect amplifies CBD's anti-inflammatory benefits

4. Multi-Pathway Anti-Inflammatory Complex

•       HERS & HIS (4.4% total): CBD 2.4% (CB2 pathway) + Copaiba 1.1% (CB2 amplification) + Frankincense 0.9% (5-LOX pathway)

•       Youth (1.6% CBD focus): Lighter inflammation profile optimized for prevention rather than correction

•       Two complementary pathways (mature skin) vs preventative approach (younger skin) = targeted efficacy

5. Climate-Optimized Stability

•       Anhydrous formulation maintains CBD potency without degradation

•       No refrigeration required (stable to 30°C in South African climate)

•       Maximum shelf-life preservation of active compounds

Result: While below the study's optimal 5% single-ingredient threshold for standard formulations, our enhanced delivery system, dual-source CBD, CB2 amplification (mature skin formulations), and multi-pathway approach maximize the therapeutic potential of our concentrations. Youth formulation uses a lighter CBD concentration appropriate for younger skin's lower inflammatory baseline and faster cellular turnover.

Implications for TrueOrganic:

•       Industry standard of 0.5-1% CBD delivers minimal skin penetration (10x less than 5%)

•       Therapeutic benefits in standard formulations require minimum 5% concentration

•       TrueOrganic's approach: optimize delivery system + synergistic amplification + age-appropriate concentrations

•       Our anhydrous delivery + multi-pathway complex + age-targeted concentrations bridge the gap

Where Referenced: How It Started (CBD concentration explanation), TrueOrganic Difference (pharmaceutical-grade approach with enhanced delivery), HERS/HIS Product Pages (2.4% CBD justification), Youth Product Page (1.6% CBD preventative approach)

STUDY 2: INDUSTRY CONCENTRATION ANALYSIS

Source: Independent laboratory testing conducted by Micro Quality Labs, Burbank, CA (October 2020 & February 2021), commissioned by Exponent Beauty.

Study Type: Independent third-party laboratory analysis of commercial skincare products

Objective: To verify actual active ingredient concentrations in popular skincare products and compare to claimed concentrations and efficacy thresholds.

Key Findings:

Starting Concentrations:

•       60% of tested products contained active ingredient concentrations below the minimum threshold required for therapeutic efficacy

•       Day 1 concentrations were 30% lower than brand claims on average

Degradation Over Time:

•       Active ingredients degraded by 40% on average within 8 weeks of opening

•       Water-based formulations showed highest degradation rates

Critical Conclusion: This systematic testing exposed the practice of "fairy dusting" or "pixie dusting" — adding buzzworthy ingredients at concentrations sufficient for label claims but insufficient for therapeutic effects. Majority of premium skincare products contain active ingredients at cosmetic concentrations (for marketing) rather than therapeutic concentrations (for results).

Implications for TrueOrganic:

•       100% anhydrous formulations maintain stability (no water = no degradation)

•       Pharmaceutical-grade concentrations cost more but deliver actual results across all three product lines

•       Third-party verification would expose gap between marketing and our reality: what we claim is actually present

SUPPORTING RESEARCH

Additional peer-reviewed studies supporting specific ingredient selections across HERS, HIS, and Youth formulations.

HERS SIGNATURE INGREDIENTS

ROSEHIP SEED OIL - Natural Retinoids

Citation: Valerón-Almazán P, Gómez-Duaso AJ, Santana-Molina N, García-Bello MA, Carretero G. "Evolution of Post-Surgical Scars Treated with Pure Rosehip Seed Oil." Journal of Cosmetic Dermatology and Sciences and Applications. 2015;5:161-167. doi: 10.4236/jcdsa.2015.52019.

Key Findings:

•       Contains trans-retinoic acid (active vitamin A)

•       75%+ essential fatty acids (linoleic and linolenic acids)

•       Proven reduction in hyperpigmentation and scarring

•       Gentle cellular turnover without retinoid irritation

Relevance to HERS: Provides natural retinoid activity for cellular renewal without irritation. Ideal for mature, hormonally-sensitive skin seeking anti-aging benefits without synthetic retinoid sensitivity.

PRICKLY PEAR SEED OIL - Exceptional Vitamin E

Citation: Ramadan MF, Mörsel JT. "Oil cactus pear (Opuntia ficus-indica L.)." Food Chemistry. 2003;82(3):339-345. doi: 10.1016/S0308-8146(02)00550-2.

Key Findings:

•       Contains over 1000mg/kg tocopherols (vitamin E) - 150% more than argan oil

•       61.4% linoleic acid for barrier support

•       Exceptional brightening and antioxidant properties

Relevance to HERS: Highest natural vitamin E concentration of any botanical oil, supporting barrier repair and delivering exceptional antioxidant protection for mature, hormonally-sensitive skin. One of the world's most expensive botanical oils.

SEA BUCKTHORN OIL - Rare Omega-7

Citation: Zielińska A, Nowak I. "Abundance of active ingredients in sea-buckthorn oil." Lipids in Health and Disease. 2017 May 19;16(1):95. doi: 10.1186/s12944-017-0469-7. PMID: 28526025.

Key Findings:

•       20-40% palmitoleic acid (rare omega-7 fatty acid)

•       Exceptionally high carotenoid content (golden color)

•       Supports skin barrier and elasticity, wound healing properties

Relevance to HERS: Provides rare omega-7 (palmitoleic acid) found in youthful skin but declining with age. Supports barrier function, elasticity, and delivers natural radiance. Critical for mature skin experiencing age-related lipid decline.

HIS SIGNATURE INGREDIENTS

POMEGRANATE SEED OIL - Omega-5 Punicic Acid

Citation: Schubert SY, Lansky EP, Neeman I. "Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids." Journal of Ethnopharmacology. 1999 Jul;66(1):11-7. doi: 10.1016/s0378-8741(98)00222-0. PMID: 10432202.

Key Findings:

•       65-85% punicic acid (conjugated omega-5 fatty acid) - unique to pomegranate

•       Potent anti-inflammatory through eicosanoid enzyme inhibition

•       Superior antioxidant activity compared to conventional seed oils

•       Regulates sebum production and supports thicker skin barrier

Relevance to HIS: Omega-5 punicic acid specifically targets male skin concerns: sebum regulation for oilier skin, enhanced anti-inflammatory support for environmental stress, and superior penetration for thicker dermis (men have 25% thicker skin than women).

COFFEE SEED OIL - Caffeine Firming

Citation: Herman A, Herman AP. "Caffeine's Mechanisms of Action and Its Cosmetic Use." Skin Pharmacology and Physiology. 2013;26(1):8-14. doi: 10.1159/000343174. PMID: 23075568.

Key Findings:

•       Topical caffeine stimulates microcirculation

•       Lipolytic effects reduce adipose tissue appearance (firming)

•       Antioxidant protection against environmental stressors

•       Enhanced penetration delivers active caffeine to deeper skin layers

Relevance to HIS: Caffeine provides visible firming effects critical for male facial aging patterns. Men experience more pronounced jowl and under-chin sagging due to gravity and thicker skin weight. Coffee seed oil delivers sustained caffeine penetration for tightening and environmental protection.

PUMPKIN SEED OIL - Zinc & Sebum Balance

Citation: Bardaa S, Ben Halima N, Aloui F, et al. "Oil from pumpkin (Cucurbita pepo L.) seeds: evaluation of its functional properties on wound healing in rats." Lipids in Health and Disease. 2016 Apr 19;15:73. doi: 10.1186/s12944-016-0237-0. PMID: 27094778.

Key Findings:

•       High zinc content (7.3mg per 100g oil)

•       Regulates sebaceous gland activity

•       Rich in phytosterols (β-sitosterol) and vitamin E

•       Anti-inflammatory and wound healing properties

Relevance to HIS: Men naturally produce more sebum due to higher testosterone levels. Pumpkin seed oil's zinc content specifically regulates sebaceous glands, preventing oily appearance while maintaining barrier integrity. Critical for male hormonal skin balance.

GOTU KOLA - Collagen Synthesis

Citation: Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. "Centella asiatica in cosmetology." Postepy Dermatologii i Alergologii. 2013 Feb;30(1):46-9. doi: 10.5114/pdia.2013.33378. PMID: 24278045.

Key Findings:

•       Asiaticoside and madecassoside stimulate collagen synthesis

•       Increases collagen type I and type III production

•       Improves wound healing and skin firmness

•       Enhances skin elasticity and reduces fine lines

Relevance to HIS: Men experience more pronounced collagen loss after age 30 (consistent 1% annual decline vs fluctuating decline in women). Gotu Kola's triterpenoid saponins actively stimulate fibroblast collagen synthesis, addressing male-specific aging patterns of sagging and deep wrinkles.

BAOBAB OIL - Multi-Vitamin Complex

Citation: Vermaak I, Kamatou GP, Komane-Mofokeng B, Viljoen AM, Beckett K. "African seed oils of commercial importance — Cosmetic applications." South African Journal of Botany. 2011 Oct;77(4):920-933. doi: 10.1016/j.sajb.2011.07.003.

Key Findings:

•       Rich in vitamins A, D, E, and F

•       High omega-3, 6, and 9 fatty acid content (optimal balance)

•       Exceptional moisturizing without greasy residue

•       Anti-inflammatory and skin-soothing properties

Relevance to HIS: Baobab provides comprehensive vitamin support critical for environmental stress recovery. Men's outdoor exposure patterns (sports, work) increase vitamin depletion. Multi-vitamin profile supports cellular repair, barrier function, and antioxidant defense without heavy texture.

YOUTH SIGNATURE INGREDIENTS

KAKADU PLUM OIL - World's Highest Vitamin C

Citation: Netzel M, Netzel G, Tian Q, et al. "Native Australian fruits—a novel source of antioxidants for food." Innovative Food Science & Emerging Technologies. 2007 Sep;8(3):339-346. doi: 10.1016/j.ifset.2007.03.007.

Key Findings:

•       Contains 3000-5000mg vitamin C per 100g (100x more than oranges)

•       Highest recorded natural vitamin C concentration in any botanical source

•       Exceptional antioxidant capacity (ORAC values exceed common antioxidants)

•       Supports collagen synthesis and brightening

Relevance to Youth: Young skin prioritizes prevention over correction. Kakadu plum delivers unprecedented vitamin C for collagen protection, free radical defense, and brightening. Lightweight oil-soluble form prevents oxidation issues common with water-based vitamin C serums. Ideal for building antioxidant reserves before age-related decline begins.

WATERMELON SEED OIL - Lightweight Non-Comedogenic

Citation: Baboli ZM, Kordi AAA. "Characteristics and Composition of Watermelon Seed Oil and Solvent Extraction Parameters Effects." Journal of the American Oil Chemists' Society. 2010 Jun;87(6):667-671. doi: 10.1007/s11746-010-1546-5.

Key Findings:

•       60-70% linoleic acid (omega-6) - matches sebum composition

•       Exceptionally lightweight texture (low molecular weight)

•       Non-comedogenic rating of 0-1 (won't clog pores)

•       Fast absorption without residue

Relevance to Youth: Young skin (18-35) often produces excess sebum and is prone to congestion. Watermelon seed oil's high linoleic acid content actually regulates sebum production (linoleic acid deficiency causes thick, acne-prone sebum). Lightweight texture prevents heaviness while delivering essential fatty acids. Perfect base for combination or acne-prone younger skin.

HEMP SEED OIL - Optimal Omega Balance

Citation: Callaway J, Schwab U, Harvima I, et al. "Efficacy of dietary hempseed oil in patients with atopic dermatitis." Journal of Dermatological Treatment. 2005 Apr;16(2):87-94. doi: 10.1080/09546630510035832. PMID: 16019622.

Key Findings:

•       Perfect 3:1 ratio of omega-6 to omega-3 (ideal for skin)

•       Contains GLA (gamma-linolenic acid) for inflammation regulation

•       Improves skin barrier function and reduces water loss

•       Balances oil production in both dry and oily areas

Relevance to Youth: Young combination skin needs omega balance without heaviness. Hemp seed oil's 3:1 omega ratio matches optimal skin requirements, regulating both dry patches and oily zones. GLA specifically addresses hormonal fluctuations common in 18-30 age range. Non-comedogenic and lightweight for daily use.

GREEN TEA EXTRACT - EGCG Preventative Protection

Citation: Katiyar SK, Elmets CA. "Green tea polyphenolic antioxidants and skin photoprotection (Review)." International Journal of Oncology. 2001 Jun;18(6):1307-13. doi: 10.3892/ijo.18.6.1307. PMID: 11351267.

Key Findings:

•       EGCG (epigallocatechin-3-gallate) provides potent antioxidant protection

•       Prevents UV-induced oxidative damage

•       Reduces inflammation and supports DNA repair

•       Preventative anti-aging effects when used consistently

Relevance to Youth: Prevention is the most effective anti-aging strategy. Green tea EGCG protects collagen from degradation before it occurs, preventing wrinkle formation rather than correcting it. Young skin has optimal collagen levels—green tea preserves them. Critical for UV-exposed lifestyles (outdoor activities, commuting). Also included in StrataPhix AOS complex for synergistic antioxidant amplification.

UNIVERSAL INGREDIENTS (HERS, HIS & YOUTH)

CBD FOR SKIN HEALTH - Comprehensive Review

Citation: Baswan SM, Klosner AE, Glynn K, et al. "Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders." Clinical, Cosmetic and Investigational Dermatology. 2020 Dec 8;13:927-942. doi: 10.2147/CCID.S286411. PMID: 33335413.

Key Findings:

•       CBD demonstrates anti-inflammatory properties relevant to all skin types

•       Modulates sebum production through endocannabinoid system

•       Antioxidant effects comparable to vitamins C and E

•       Higher concentrations (1-10% range) show enhanced efficacy

Relevance Across Product Lines: CBD forms the foundation of all three formulations, with concentrations optimized for age and skin needs. HERS/HIS (2.4%) targets mature inflammatory skin, while Youth (1.6%) provides preventative anti-inflammatory support appropriate for younger skin's lower baseline inflammation and faster cellular turnover.

COPAIBA OIL - CB2 Receptor Activation (HERS & HIS)

Citation: Gelmini F, Beretta G, Anselmi C, et al. "GC-MS profiling of the phytochemical constituents of the oleoresin from Copaifera langsdorffii Desf. and a preliminary in vivo evaluation of its antipsoriatic effect." International Journal of Pharmaceutics. 2013 Feb 25;440(2):170-8. doi: 10.1016/j.ijpharm.2012.08.021. PMID: 22906769.

Key Findings:

•       Beta-caryophyllene is primary active (30-60% of copaiba oil)

•       Acts as selective CB2 receptor agonist (same receptor as CBD)

•       Synergistic anti-inflammatory effects with cannabinoids

Relevance to HERS & HIS: Copaiba's beta-caryophyllene amplifies CBD's CB2 receptor activation. Mature skin (35+) experiences chronic low-grade inflammation. This dual CB2 activation provides enhanced anti-inflammatory support beyond CBD alone. Critical component of our 4.4% Dual-Pathway CB2 Complex. Omitted from Youth due to lower inflammatory baseline in younger skin.

STRATAPHIX AOS - Advanced Antioxidant Synergy (All Products)

Composition: Caprylic/Capric Triglyceride (95-98%) + Camellia Sinensis (Green Tea) Leaf Extract (0.7-2.0%) + Lithospermum Erythrorhizon Root Extract (0.1-0.7%) + Haematococcus Pluvialis Extract (Astaxanthin, 0.1-0.7%) + Glycyrrhiza Glabra (Licorice) Root Extract (0.001-0.005%)

Supporting Research:

Astaxanthin (Haematococcus):

Citation: Tominaga K, Hongo N, Karato M, Yamashita E. "Cosmetic benefits of astaxanthin on humans subjects." Acta Biochimica Polonica. 2012;59(1):43-7. PMID: 22428137.

•       6000x more powerful antioxidant than vitamin C

•       Superior UV protection and anti-inflammatory effects

•       Reduces fine lines and improves skin elasticity

Green Tea Extract (Camellia Sinensis): (See detailed Youth section above) - EGCG provides photoprotection and preventative anti-aging

Licorice Root Extract (Glycyrrhiza Glabra):

Citation: Leyden JJ, Shergill B, Micali G, Downie J, Wallo W. "Natural options for the management of hyperpigmentation." Journal of the European Academy of Dermatology and Venereology. 2011 Oct;25(10):1140-5. doi: 10.1111/j.1468-3083.2011.04130.x. PMID: 21729120.

•       Glabridin inhibits tyrosinase (melanin production)

•       Brightening and anti-inflammatory properties

•       Reduces hyperpigmentation without irritation

Relevance Across All Products: StrataPhix AOS delivers multi-mechanism antioxidant protection through synergistic botanical extracts. Astaxanthin provides exceptional free radical defense (6000x vitamin C), green tea EGCG prevents UV damage, and licorice brightens. MCT (Caprylic/Capric Triglyceride) carrier ensures stability and enhanced penetration. Present in all three formulations as our Advanced Antioxidant Complex.

FORMULATION PHILOSOPHY REFERENCES

Scientific principles supporting TrueOrganic's core formulation pillars across all product lines.

WATER-FREE FORMULATIONS

Principle: 100% anhydrous formulations deliver maximum active concentration without water-related compromises.

Supporting Evidence:

•       Water dilutes active ingredients (typically 60-80% of conventional formulas)

•       Requires emulsifiers (10-15%), preservatives (3-5%), thickeners (5-10%)

•       Anhydrous formulations = ~40% active ingredients vs 5-10% in water-based

•       Enhanced stability (no microbial growth, no oxidation from water exposure)

TrueOrganic Application: Our 100% anhydrous formulations eliminate water entirely, replacing it with therapeutic concentrations of certified organic oils and butters. Every molecule works for your skin across all three product lines.

GENDER & AGE-SPECIFIC FORMULATION

Principle: Men's and women's skin have distinct biological differences requiring targeted formulation approaches.

Supporting Research:

Citation: Dao H Jr, Kazin RA. "Gender differences in skin: a review of the literature." Gender Medicine. 2007 Dec;4(4):308-28. doi: 10.1016/s1550-8579(07)80061-1. PMID: 18215723.

Key Findings:

•       Male skin is 25% thicker with more collagen density

•       Men produce 2x more sebum due to higher testosterone levels

•       Men lose collagen consistently (1% annually) vs women's hormonal fluctuations

•       Different aging patterns: men experience more pronounced jowl/chin sagging

•       pH differences affect product absorption and efficacy

TrueOrganic Application: HIS formulation specifically addresses male skin biology: enhanced penetration for thicker dermis (Coffee seed oil, Pomegranate omega-5), sebum regulation (Pumpkin seed zinc), consistent collagen support (Gotu Kola), and masculine sensory profile (Sandalwood, Cedarwood essential oils). HERS addresses hormonal fluctuations with Dual-Pathway CB2 Complex and barrier-supporting oils. Youth focuses on prevention with lightweight, non-comedogenic delivery.

CELLULAR TRANSFORMATION TIMELINE

Scientific Basis for Realistic 6-8 Week Transformation Expectations

Skin Cell Turnover Cycle:

Citation: Rittié L, Fisher GJ. "Natural and sun-induced aging of human skin." Cold Spring Harbor Perspectives in Medicine. 2015 Jan 5;5(1):a015370. doi: 10.1101/cshperspect.a015370. PMID: 25561721.

Average Cellular Turnover by Age:

•       Ages 18-25 (Youth target): ~20-28 days

•       Ages 25-35 (Youth/HERS transition): ~28-35 days

•       Ages 35-50 (HERS/HIS primary): ~35-45 days

•       Ages 50+ (HERS/HIS mature): ~45-60 days

Implication: Visible transformation requires at least one complete cellular turnover cycle. For Youth users (18-35), results may appear by Week 4-6. For HERS/HIS users (35-65), 6-8 weeks minimum is realistic. This is why we set honest transformation timelines rather than promising "instant results."

HOW TO USE THIS DOCUMENT

For Customers

This document provides complete scientific backing for all claims made across the TrueOrganic website. If you see a concentration claim, ingredient selection, or timeline expectation, the supporting research is documented here with full citations. We've been transparent about our age and gender-specific formulation approaches.

For Healthcare Professionals

We welcome scrutiny from dermatologists, estheticians, and healthcare providers. All claims are backed by peer-reviewed research. We're honest about our concentration optimization strategies across different age groups and genders. Contact us for additional information.

For Transparency

This level of disclosure is unusual in the skincare industry. We provide it because we're confident in our formulation approach and believe educated customers make the best long-term partners. We're honest about gender and age-specific optimizations rather than claiming "one size fits all."

DISCLAIMER

The research cited in this document supports specific ingredient selections, concentrations, and formulation principles used by TrueOrganic across HERS, HIS, and Youth product lines. Individual studies referenced were not conducted by TrueOrganic but by independent researchers at accredited institutions.

TrueOrganic formulations are cosmetic products, not pharmaceutical drugs. While we formulate based on pharmaceutical research and optimize delivery systems for maximum efficacy, our products are not intended to diagnose, treat, cure, or prevent any disease.

Results may vary by individual. Transformation timelines (4-8 weeks depending on age) are based on average cellular turnover rates documented in scientific literature, but individual responses depend on age, skin condition, genetics, product line selection, and consistent use.

Last Updated: January 27, 2025

Document includes HIS and Youth formulation research additions. Contact: info@trueorganic.co.za for questions.